Alexander Meissner, Ph.D.
The Meissner laboratory uses genomic tools to study stem cell biology, with a particular focus on epigenetic reprogramming.
The term "epigenetic" refers to stable modifications of the chromatin and DNA that do not alter the primary nucleotide sequence. The global epigenetic makeup of a cell is a powerful indicator of its developmental state and potential.
We apply next-generation sequencing technologies to study the epigenome in early development, stem cells and cancer. We are developing and applying high-throughput bisulfite sequencing (HTBS) technologies for genome-wide (nucleotide resolution) DNA methylation analysis.
To gain insights into the interaction and regulation of epigenetic modifications (histone modifications and DNA methylation), we use loss-of-function and gain-of-function systems.
Pluripotent stem cells have enormous potential for regenerative medicine, and provide a powerful tool for studies in developmental biology and pharmacology. Recent advances in transforming somatic cells directly into pluripotent (iPS) cells provide an attractive avenue for generating patient-specific stem cells. Our lab is identifying the epigenetic changes and components involved in reprogramming and maintaining cellular states.
- Webinar: The evolving landscape of epigenomics: Measuring and manipulating methylation
- Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in chronic lymphocytic leukemia
- Mapping the epigenome
- Stem cells prepare early for differentiation