William T. Pu, MD
Harvard Medical School
The Pu laboratory studies the regulation of gene expression in heart development and heart failure with the goal of applying their new knowledge towards regenerative approaches to congenital and acquired heart disease.
Research in William T. Pu's laboratory seeks new insights into:
- the transcriptional network regulating heart development and disease,
- cell lineage specification in heart development and regeneration, and
- genetic contributions to congenital heart disease.
The Pu lab is interested in the regulation of gene expression and cell lineage specification in heart development, disease, and regeneration. Major technologies employed include: genetically engineered mice, conditional gene inactivation, genome-wide chromatin occupancy analysis, and RNA expression profiling.
Dr. Pu received an MD from Harvard Medical School. He completed his internship, residence, and pediatric cardiology training at Boston Children's Hospital.
- Proposed gene therapy for a heart arrhythmia, based on models made from patient cells
- Gene therapy reverses heart failure in mouse model of Barth syndrome
- Catch the Rhythm: Tissue models, potential gene therapy for deadly heart arrhythmia
- Patient stem cells used to make ‘heart disease-on-a-chip’
- Modified RNA offers drug-like approach to regenerating heart tissue